![]() The resulting lozenges were tested of its uniformity of weight, hardness tested tablets, fragility and responses to the taste. The dried granule then mixed with a lubricant and tested for the properties such as free flowing. The lozenges was created in 5 formula based on a combination of sucrose: manitol, F1 (0%: 100%) F2 (25% 75%) F3 (50%: 50%) F4 (75%: 25%) F5: 25% (75%) using a 5% aqueous gelatin as a binder. The extract was made by maceration of simplisia using ethanol 70%, thickened and then dried using the tool freeze dryer. A Simple method of Lattice Design was used to know the influence of the combination physical properties of granule and lozenges and also predicting which formula is optimal. Extract of guava leaves was formulated into several dosages of lozenges in combination with fillers manitol-sucrose. The aim of this study is to formulate an acceptable guava leaf extract preparations. Flavonoid compounds found on the leaves of the guava are known to have an antibacterial activity. ![]()
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